#210 Will Caffeine Make You Live Longer? Interleukin 1β and Inflammation

Will Caffeine Make You Live Longer?

According to a recent Stanford University study, caffeine may block age-related inflammation and extend life.  This study follows in line with many other studies also showing that natural sources of caffeine may lengthen your lifespan.  In this article, I review the science and answer the question, will caffeine make you live longer?

The Stanford Caffeine Study

In blog #197, I discussed how keeping inflammation levels as low as possible may help you live to age 110.  As my blog readers know, inflammation is one of the main causes of heart disease, dementia, and cancer.

In this Stanford study, researchers also came to the same conclusion.  Age-related inflammation is the major driver of health and longevity in humans.

As part of their experiment, they wanted to see if caffeine could make you live longer by blocking this age-related inflammation.  To do this, they recruited about a hundred people, followed them for many years, and closely monitored which genes were turned on and which were turned off.

In particular, they were focussed on the inflammatory molecule interleukin 1β.   Interleukin 1β is an age-related molecule that is readily seen as people get older and have many medical conditions.

What they found was really quite interesting.  Those people consuming the highest levels of natural caffeine had very low expression of genes associated with inflammation or interleukin 1β.  Thus, people regularly consuming natural caffeine were much less likely to have cardiovascular disease and other age-related diseases.

Intrigued by this link between caffeine and aging, Stanford researchers then gave mice caffeine and observed that the caffeine shut down age-related inflammation.  In particular, this caffeine shut down gene expression of interleukin 1β.

Other Caffeine and Longevity Studies

This Stanford study is not the only study that has linked caffeine to longevity.  For example, it is well-known from other studies that if you give caffeine to worms, flies, or mice that they will live longer.  In mice, caffeine also seems to prevent dementia.

While most people would prefer that worms, flies, or mice don’t live longer, there are other studies showing that humans also live longer with natural caffeine.  Indeed, a recent Harvard study of 133,611 people showed that those consuming the highest amounts of natural caffeine lived 12% longer than those not getting any natural caffeine.

Natural vs. Artificial Caffeine

There is a difference between natural and artificial sources of caffeine.  For example, I have yet to see a study which says that drinking soda pop or Red Bull or even eating milk chocolate makes you live longer.  In contrast, there have now been many studies linking dark chocolate, tea, and coffee to longevity.

How might caffeine make you live longer?

Intuitively, it doesn’t make sense that caffeine might extend your life.  After all, caffeine raises your blood pressure and heart rate.  These effects would be expected to shorten your life, not extend it.

Perhaps caffeine really has nothing at all to do with longevity.  This could explain why artificial caffeine has never been shown to improve health whereas dark chocolate, tea, or coffee may offer some health benefit.

For example, dark chocolate, tea, and coffee are all high in antioxidants.  Antioxidants are molecules that block free radicals in your body.  Free radicals are byproducts of your body making energy.  Free radical production is also one of the major causes of aging and inflammation.  Outside of fruits and vegetables, dark chocolate, tea, and coffee have some of the highest concentrations of antioxidants measured.

Alternatively, it could also be other metabolites such as theophylline and theobromine which are abundant in natural caffeine sources.  These metabolites might also have a beneficial effect that we don’t fully understand at this time.

Take Home Message

The most important thing to take away from this article is that these studies don’t provide any conclusive proof that natural caffeine will make you live longer.  All we can say is that many studies have shown a link between natural caffeine sources and human longevity.

Thus, the research isn’t strong enough that natural caffeine products be recommended to anyone.  However, if you like the taste of dark chocolate, tea, or coffee then the studies reviewed in this article will be reassuring to you.

It goes without mention that you need to approach natural caffeine products with common sense.  These should only be taken in moderation if at all.

If dark chocolate is your preferred natural caffeine source, then the less sugar you get with your dark chocolate the better.  Ideally, your dark chocolate will also be as close to 100% cacao as you can tolerate.

For coffee lovers, the cream and sugar could completely undo any possible health benefits of this drink.  Likewise, drinking too much coffee or tea could trigger cardiac arrhythmias, insomnia, tremors, and other problems.

What’s your take on these natural caffeine longevity studies?

Please leave your thoughts and questions below.  I’ll do my best to answer any question within 24 hours.  Of course, if you haven’t yet subscribed to my free weekly newsletter or podcast, now would be a great time by following these links!

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    • Hi Steve,

      There are some studies showing that decaf coffee may have the same health benefits. However, none of these studies are conclusive. That is why I cannot recommend drinking regular coffee or decaf coffee for health reasons.


  1. What about caffeine tablets? Is it this caffeine natural or artificial? Was the caffeine fed to the mice, worms, and flies in the studies natural or artificial? Seems like tablets avoid the sugar, but do the tablets have a downside, assuming dosage is appropriate and safe? Always enjoy your articles. I’m increasing my intake of vegetables and fruits, and I feel better. Thanks.

    • Hi Richard,

      Thanks for reading! Great questions. Caffeine tablets in humans have never been shown to improve health. You have to be very careful interpreting studies from mice, worms, and flies. At best, only 10% of what works in animals translates to humans. For flies and worms this percentage is much lower. You are correct in that in these studies the caffeine was medicinal quality without sugar.

      Hope this helps!


  2. Thank you for contributing so much to health and well-being for so many. The content and approach of your articles is extremely helpful.

    Thank you!

  3. Fairly certain that the cacao bean only contains something like caffeine, but no true caffeine at all. Eating only good, unprocessed food and doing some kind of exercise at least once a day is my credo for staying alive and reversing age-related ailments… All thanks to Dr. Day’s recommendations.

  4. My mother lived to 91, and at one time, she was drinking FIVE pots of coffee every day! Now, I believe that she did suffer some health issues from the consumption of so much bitter drink. She had a hiatus hernia. Now her sister is now 97, and she has always been a health nut. Each day, she drinks five cups of green tea sweetened with natural organic honey. She never smoked or drank alcohol. My mother smoked for seven years in her early teens and twenties, but then she stopped. She died from a bunch of tiny blood clots cause when she stopped taking her blood pressure medicine. Her doctor said “Your blood pressure is normal.” My mother interpreted that (in her 80s) as meaning she could stop taking her blood-pressure medicine! DOCTORS! NEVER TELL ON OLD PERSON ON BLOOD PRESSURE MEDICINE THAT THEIR BLOOD PRESSURE IS NORMAL!!!

    • I am 70 and due to blood pressure meds and diuretics, my kidneys aren’t producing sufficient erythropoeitin to make my bone marrow produce healthy red blood cells. I’m trying to reverse the resultant anemia by reducing the dosages of meds including aspirin (to prevent clots associated with AFib). Will see if my strategy raises my HCT and HGB levels.