#377 Slow Aging with Vitamin D, Omega-3s, and Exercise: Science-Backed Strategies
February 22nd, 2025 by Dr. John DaySlow Aging with Vitamin D, Omega-3s, and Exercise: Science-Backed Strategies
Aging is inevitable, but what if you could slow it down? New research from the DO-HEALTH trial suggests that three simple lifestyle habits—taking vitamin D, consuming omega-3s, and doing regular exercise—can help slow biological aging. These findings could mean more energy, fewer illnesses, and a longer, healthier life. Let’s break down the science and how you can apply it to your daily routine.
The Science Behind “Slow Aging”
Aging isn’t just about wrinkles and gray hair—it’s happening deep inside your cells. Scientists measure biological aging using DNA methylation (DNAm) clocks, which track changes in DNA that influence aging. The DO-HEALTH trial studied how vitamin D, omega-3s, and exercise affected these aging markers in 777 healthy 70 year olds over three years.
What They Found:
1. Omega-3s slowed biological aging across multiple DNAm clocks.
2. Vitamin D and exercise had additional benefits, especially when combined with omega-3s.
3. The combined effect of all three interventions was the strongest, showing a clear advantage in slowing aging and reducing disease risk.
How Much Can You Slow Aging?
In the study, participants who followed these interventions experienced a biological aging slowdown of about 2.9 to 3.8 months over three years. This may seem small, but when combined with other healthy habits, the effects can accumulate, potentially adding years of quality life.
Beyond slowing aging, the study also found that:
1. Omega-3s reduced infections by 13% and falls by 10%.
2. The combination of all three interventions cut the risk of frailty by 39%.
3. They also reduced invasive cancer risk by a staggering 61%!
How to Apply These Anti-Aging Strategies
The best part? These interventions are easy, affordable, and completely natural. Here’s how you can incorporate them into your life today.
1. Get Enough Vitamin D
Vitamin D is crucial for immune function, bone health, and reducing inflammation—all factors that influence aging. The study participants took 2,000 IU daily, which is a safe and effective dose for most adults.
How to Get It 2000 IU of vitamin D daily:
1. Sunlight exposure in a “sun safe” way to avoid any burning (15–30 minutes daily on bare skin)
2. Vitamin D supplements (especially if you live in a colder climate or have had blood tests showing low vitamin D levels)
3. Foods like salmon, fortified dairy, and eggs
Vitamin D deficiency is widespread, especially among those who spend a lot of time indoors. If you’re unsure about your levels, consider getting tested and adjusting your intake accordingly.
2. Eat Omega-3-Rich Foods
Omega-3 fatty acids, particularly EPA and DHA, are powerful anti-aging nutrients that support brain health, heart health, and reduce inflammation.
How to Get 1 Gram of Omega-3s Daily:
– 1 ounce (28g) of wild salmon
– 7 walnut halves
– 1.5 teaspoons of flaxseeds
– ½ teaspoon of chia seeds
I personally get my omega-3s from wild salmon, chia seeds, and flaxseeds. While I used to take fish oil, I stopped due to concerns about atrial fibrillation (Afib), as some studies suggest a potential link. Instead, I get my omega-3s naturally through whole foods.
Another great way to incorporate omega-3s into your diet is by adding walnuts, flaxseeds, or chia seeds to smoothies, yogurt, or oatmeal. They provide fiber, protein, and essential fatty acids, making them an excellent addition to a healthy diet.
While both fish and plant-based sources like walnuts, chia seeds, and flaxseeds provide omega-3 fatty acids, they are not identical in form or function. Fish contains EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), the two most bioavailable and beneficial forms of omega-3s for heart, brain, and cellular health. In contrast, plant-based sources provide ALA (alpha-linolenic acid), which the body must convert to EPA and DHA, though this conversion is inefficient—only about 5-15% of ALA is converted. While plant-based omega-3s still offer benefits, especially for those on a vegetarian or vegan diet, consuming fatty fish like salmon ensures direct access to the most potent forms of omega-3s with superior anti-inflammatory and cognitive support properties.
3. Strength Training 30 Minutes, 3 Times Per Week
The study participants followed a strength-training exercise program for 30 minutes, three times per week. This type of workout improves muscle strength, balance, and metabolic health—all key for longevity.
How to get 30 minutes of strength training, 3 times per week:
Strength training can take many forms and doesn’t require a gym membership. For example, Everyday activities like carrying groceries, gardening, or climbing stairs also count as functional strength training. No matter your fitness level, incorporating strength training at least three times a week—whether at home, in a gym, or through activities you enjoy—can make a profound difference in slowing the aging process and maintaining overall health.
Bodyweight exercises such as squats, push-ups, lunges, and planks provide resistance and build strength without any equipment. Resistance bands add variety and challenge with exercises like lateral band walks and seated rows.
Free weights, like dumbbells or kettlebells, allow for functional strength training with movements like deadlifts, shoulder presses, and bent-over rows. Machines at the gym offer controlled resistance exercises, such as leg presses and lat pulldowns, while TRX suspension training uses body weight for full-body resistance.
Consistency is key! Even small amounts of regular movement can have profound effects on aging and overall well-being. If you’re new to exercise, start with a routine you enjoy and build from there. Walking is an excellent starting point, and as you gain strength, adding resistance training will further support longevity.
Additional Benefits Beyond Slow Aging
Aside from slowing aging, these interventions provide a host of other health benefits. Vitamin D has been shown to boost mood and immune function, while omega-3s support cognitive health, reducing the risk of neurodegenerative diseases like Alzheimer’s. Exercise not only improves physical strength but also enhances mental health by reducing stress and anxiety.
Research shows that a combination of these interventions contributes to a lower risk of chronic diseases such as diabetes, heart disease, and osteoporosis. By taking proactive steps today, you can improve your quality of life well into your later years.
Why This Matters for You
The DO-HEALTH trial provides compelling evidence that you can take control of your biological aging. By making small, consistent changes, you may not only slow aging but also lower your risk of infections, falls, frailty, and even cancer.
These findings align with what I’ve personally practiced for the past 13 years since our first visit to China’s Longevity Village, which became the foundation of our bestselling book, The Longevity Plan. I take 2,000 IU of vitamin D daily, eat 1 ounce of wild salmon, and include chia and flaxseeds in my diet every day. In addition, I make time for at least one hour of exercise daily, prioritizing both strength training and cardiovascular fitness. This commitment to daily movement has been a game-changer for my own health, and I encourage my patients to adopt similar habits for a longer, healthier life.
Final Thoughts
Slowing aging doesn’t require fancy supplements or extreme diets. The key is simplicity and consistency. A few small daily habits—taking vitamin D, eating omega-3-rich foods, and exercising—can make a meaningful difference in how you age.
Remember, it’s never too late to start. Whether you’re in your 30s, 50s, or beyond, making these changes today can lead to a healthier, more vibrant future. Start with one small step—whether it’s adding a few extra minutes of sunlight exposure, swapping in omega-3-rich foods, or doing a quick strength-training session. Your future self will thank you!
Disclaimer
This blog post is for informational purposes only and is not intended as medical advice. Always consult with your healthcare provider before making any changes to your diet, supplement regimen, or exercise routine, especially if you have underlying health conditions or are taking medications.
About the Photo
The photo accompanying this article was taken by my wife during a recent day at Park City Mountain Resort. She has a deep appreciation for nature and especially loves capturing the beauty of her favorite trees—aspen trees—while skiing through the scenic mountain landscape.