#373 Six Simple Lab Tests that Predict Whether You’ll Live to 100
December 28th, 2024 by Dr. John DaySix Simple Lab Tests that Predict Whether You’ll Live to 100
Imagine celebrating your 100th birthday with family and friends, full of energy and vitality. Sounds like a dream, doesn’t it? A recent study has shed light on how optimizing six simple lab tests could predict whether you’ll live to 100. These tests are likely already part of your annual check-up with your primary care physician. As you read this article, it might be helpful to review your own lab results so you can follow along and see where you stand.
Let’s dive into what this study found and what you can do to tilt the odds in your favor.
What Did this New Study Discover?
Researchers compared lab test results of individuals who lived to 100 years or more (“centenarians”) with those of their shorter-lived peers. By analyzing biomarker profiles—measurements of various substances in the blood—they found that centenarians consistently had healthier values in several areas as early as age 65. This means that the road to exceptional longevity might begin decades before reaching the century mark.
Here are some of the key findings:
1. Optimized Levels of Total Cholesterol: While high cholesterol is often viewed negatively, not all cholesterol is bad. The type and distribution of cholesterol—such as higher HDL (“good” cholesterol) versus LDL (“bad” cholesterol)—may be more important than the total number. Cholesterol is essential for building cell membranes and producing hormones, and having the right balance supports overall health. For younger and middle aged people, lower levels of total cholesterol are associated with better cardiovascular function and longevity. However, in those age 85 or older, higher levels of total cholesterol while still keeping LDL low may be best. Work closely with your physician to optimize your cholesterol numbers for longevity.
2. Higher Levels of Iron and Total Iron-Binding Capacity: Iron is vital for carrying oxygen in the blood and supporting energy levels. Adequate iron levels prevent anemia, which is common in aging populations and can lead to fatigue, weakness, and impaired cognitive function. Having sufficient iron supports longevity by ensuring that tissues and organs receive the oxygen they need to function optimally. Total iron-binding capacity (TIBC) reflects your body’s ability to transport and regulate iron, ensuring levels are neither too high nor too low.
3. Lower Levels of Glucose: Elevated blood sugar levels can damage blood vessels and lead to chronic diseases.
4. Lower Levels of Creatinine: Creatinine is a waste product filtered by the kidneys. Lower levels indicate that your kidneys are functioning efficiently, which is crucial for removing toxins from the body and maintaining overall health.
5. Lower Levels of Uric Acid: Uric acid is another metabolic byproduct that, in excess, can lead to conditions like gout or kidney stones. More importantly, uric acid serves as a marker of inflammation and is a powerful predictor of your likelihood of suffering a heart attack, atrial fibrillation (AFib), or heart failure. Maintaining lower levels is protective for your cardiovascular health.
6. Lower Levels of Liver Enzymes: Markers like aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) were lower in centenarians, pointing to healthier liver function.
What Do These Lab Tests Mean?
Understanding your lab tests is the first step toward taking control of your health. Here’s what some of these biomarkers indicate:
1. Cholesterol: While too much LDL (“bad cholesterol”) can clog arteries, HDL (“good cholesterol”) helps clear it away. A balanced cholesterol profile supports heart health.
2. Iron and Total Iron-Binding Capacity (TIBC): These markers assess iron status and reflect your body’s ability to maintain an adequate supply of red blood cells to deliver oxygen throughout the body. Both deficiency and overload can harm your health, so balance is key. For example, too much iron increases the risk of oxidative stress and cardiovascular disease, while too little can lead to anemia and fatigue. Longevity studies suggest that maintaining low-normal iron levels may be optimal for reducing oxidative damage and promoting long-term health. Iron is a more significant issue for women, particularly during their menstruating years, when blood loss increases the risk of deficiency.
3. Glucose: High glucose levels may signal prediabetes or diabetes, conditions that accelerate aging by damaging blood vessels and nerves.
4. Creatinine: This waste product reflects kidney function. Lower levels suggest kidneys are filtering blood efficiently.
5. Uric Acid: Excess uric acid can lead to gout and kidney stones. Keeping it in check supports joint and kidney health.
6. Liver Enzymes (AST, GGT): Elevated levels can indicate liver stress or damage. Lower values often reflect a well-functioning liver.
How Can You Improve Your Numbers?
The great news is that you have the power to influence many of these biomarkers through lifestyle changes. Here are some actionable steps you can take:
1. Nourish Your Body
Eat a Balanced Diet: Focus on whole, minimally processed foods. Incorporate fruits, vegetables, legumes, whole grains, lean proteins, and healthy fats like nuts, seeds, or olive oil.
Mind Your Cholesterol: Increase your intake of foods rich in omega-3 fatty acids (like salmon and walnuts) and soluble fiber (like vegetables and beans) to boost HDL and lower LDL cholesterol.
Control Blood Sugar: Reduce refined carbohydrates and added sugars. Opt for low-glycemic foods like leafy greens, legumes, and nuts.
Balance Your Iron: Eat iron-rich foods like spinach, legumes, and lean meats alongside vitamin C-rich foods (like lemon, broccoli, citrus fruits, etc.) to enhance absorption. Most men should avoid iron supplementation altogether unless prescribed by their physician. For menstruating women, avoid excess supplementation unless directed by your doctor.
2. Stay Active
Move Daily: Regular physical activity improves nearly every biomarker mentioned in the study. Aim for a mix of aerobic exercise (like walking or cycling) and strength training.
Be Consistent: Even moderate activity, like a daily 30-minute brisk walk, can have profound effects on your health.
3. Protect Your Liver
Limit Alcohol: Excessive drinking can raise liver enzyme levels and damage organs over time.
Optimize Your Weight: Excessive weight is now the number one cause of fatty liver and liver failure in the US.
Avoid Unnecessary Medications: Overuse of certain medications, like acetaminophen, can strain the liver.
Avoid Excessive Supplementation: Common supplements like excessive iron, turmeric, green tea extract, niacin, and vitamin A can all be toxic to the liver when taken in high doses or over long periods. Always consult your physician.
4. Protect Your Kidneys
Stay Hydrated: Drinking enough water supports kidney function and helps flush out waste products.
Minimize Kidney-Toxic Medications: Work with your physician to reduce or manage the use of certain medications that can harm the kidneys, such as specific antibiotics, excessive diuretics, and proton pump inhibitors. Regular monitoring can help mitigate these risks.
4. Reduce Inflammation
Eat Anti-Inflammatory Foods: Include foods like berries, leafy greens, nuts, seeds, and olive oil that fight inflammation.
Manage Stress: Chronic stress increases inflammation. Practice mindfulness, yoga, or other stress-relief techniques.
Get Quality Sleep: Aim for 7-8 hours of restorative sleep each night.
5. Monitor Your Health
Regular Check-Ups: Annual lab tests can help track your progress and catch potential issues early.
Know Your Numbers: Understanding your biomarkers empowers you to make informed decisions.
How Could These Changes Prolong Your Life?
Maintaining optimal biomarker levels can help you avoid chronic diseases, such as heart disease, diabetes, and kidney failure—all of which shorten life expectancy. Here’s how healthier numbers might add years to your life:
Better Heart Health: Balanced cholesterol and lower glucose levels reduce the risk of heart attacks and strokes.
Improved Metabolism: Lower uric acid and glucose levels support healthier cells and less oxidative stress.
Stronger Organs: Healthy liver and kidney function means your body can detoxify and regulate nutrients effectively.
Reduced Inflammation: Chronic inflammation accelerates aging and damages tissues. Keeping it in check can slow aging.
Your Journey to 100 Starts Today
Living to 100 might sound like a lofty goal, but the foundation for exceptional longevity begins with small, consistent choices. You don’t need perfect genes to extend your life. By taking control of your health—through diet, exercise, and regular check-ups—you can influence your biomarkers and create a healthier future.
Your lab results aren’t just numbers on a page. They’re a window into your body’s inner workings and a guide to living your best life. Start making changes today, and who knows? You might just find yourself blowing out 100 candles someday.
Disclaimer
The information provided in this article is for general informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. Reliance on any information provided herein is solely at your own risk.
About the Photo
The attached photo captures our red Labrador, Ruby, at the top of Peak 5 at Park City Mountain Resort in Utah. Taken after November’s first significant snowfall, it showcases her love for snowy adventures. Peak 5, located on the Canyons side of Park City Mountain Resort, is renowned for its challenging terrain, including the expert-level Abyss glades. The area offers some of the most demanding tree skiing in the resort, attracting advanced skiers and snowboarders seeking thrilling experiences.